癌症医生担心超级细菌一项调查显示，那些不能用抗生素治疗的患者将很快不再将化疗作为他们患者的治疗选择。癌症患者更容易受到感染，因为疾病及其治疗可以停止免疫系统无法正常工作。
在2019年12月20日至2020年2月3日期间接受调查的100名英国肿瘤学家中经度奖95%的人表示他们担心这种影响超级细菌可能会影响他们的病人。
根据报告作者引用的现有研究，估计五分之一的癌症患者在治疗期间需要抗生素，包括多发性癌症骨髓瘤急性的白血病没有它们就无法治疗。
调查显示，46%的医生认为抗药性细菌会导致化疗不可行。28%的癌症医生预测，报告中没有提到的一些癌症疗法将在五年内被淘汰。另有39%的人预测这将在未来十年内发生，15%的人预计在20年内发生。
丹尼尔伯曼全球卫生总监内斯特挑战这是经度奖，解释给新闻周刊研究人员没有询问具体和个别类型的治疗方法，因为“所有的病人护理都是个别和多层次的，涉及许多不同类型的联合治疗和疗法。
“然而，因为我们知道化疗会抑制免疫系统，使患者容易感染，所以我们确实想进一步探索这个问题，”他说。
十分之四(41%)的人表示，他们看到去年出现耐药性感染的患者有所增加，平均有23%的癌症患者在治疗期间出现感染。
多达65，000名癌症患者有患癌症的风险超级细菌数据显示，这十年来，在英国接受手术后的感染。在接受调查的医生中，5%接受手术的病人出现了对抗生素无反应的感染。
共有86%的医生说葡萄球菌、大肠杆菌大肠杆菌和赝蒙纳将癌症患者置于严重伤害的最大风险。该研究还强调了临床医生对感染诊断方式的不满，60%的人表示实验室花了太长时间在他们的病人身上识别它们。
伯曼 在一份声明中说:“肿瘤学家担心他们的病人在手术后或接受化疗时会出现越来越多的抗生素耐药性，这是正确的。我们不能为了停止而改变生物学的规则超级细菌但是我们可以减缓它们的发展，改善感染控制和预防。"
这项研究是在专家试图阻止不能用抗生素治疗的细菌的增长的时候进行的。相应的给联合国，每年至少有70万人死于抗药性感染。报告中引用的研究表明，到2050年，这个数字可能会飙升至一千万。
伯曼报告中强调:“自20世纪80年代以来，没有发现新的抗生素种类，缺乏研发的市场激励机制导致了抗生素的大量使用制药公司工业将很大程度上放弃开发新疗法的项目。
“尽管英国和美国为研究提供了大量补贴，最近也努力增加新抗生素的支付，但市场仍不景气，最近抗生素[研发]生物技术公司的破产敲响了警钟其中医学界。"
伯曼讲述新闻周刊在阻止抗生素耐药性恶化方面，我们都有自己的一份责任，包括听取卫生保健专业人士的意见，他们告诉我们除非必要，否则不要使用抗生素。
引用数据美国疾病控制和预防中心去年年底发布的报告称，美国每年有超过280万例抗生素耐药性感染，超过35，000人因此死亡。伯曼他说，“我们可以得出结论，美国的肿瘤学家和英国的同行有着同样的担忧。”
对于因这些发现而担忧的癌症患者来说，伯曼强调:“今天，接受化疗的患者可以放心，绝大多数感染可以成功预防或用抗生素治疗。
“这项研究给我们敲响了警钟，告诉我们需要新的诊断测试，这样我们才能更好地使用抗生素，确保它们继续发挥作用。如果阻力水平继续上升，问题将变得更加严重。”
伯曼补充道:“最终，抗生素耐药性会影响世界上任何年龄、任何地点的任何人，这些数字应该给我们所有人敲响警钟。”
这篇文章已经更新了丹尼尔的评论伯曼。
CHEMOTHERAPY FOR CANCER TREATMENT COULD SOON BE UNVIABLE BECAUSE OF ANTIBIOTIC-RESISTANT SUPERBUGS, DOCTORS FEAR
Cancer doctors fear superbugs which can't be treated with antibiotics will soon remove chemotherapy as a treatment option for their patients, a survey has revealed. Cancer patients are more vulnerable to infections because the disease and its treatments can stop the immune system from working correctly.
Of the 100 oncologists in the U.K. surveyed between December 20, 2019 and February 3, 2020 by the Longitude Prize—which was established to help tackle antimicrobial resistance—95 percent said they were worried about the effect superbugs could have on their patients.
An estimated one in five cancer patients need antibiotics during their treatment, according to existing research cited by the authors of the report, and cancers including multiple myeloma and acute leukaemia can't be treated without them.
The survey revealed that 46 percent of doctors believe drug-resistant bugs will make chemotherapy unviable. Some cancer treatments, which the report didn't name, will be obsolete in five years, 28 percent of the cancer doctors predicted. A further 39 percent forecast this would happen within the next decade, and 15 percent in two decades.
Daniel Berman, global health director of Nesta Challenges which runs the Longitude Prize, explained to Newsweek that the researchers didn't ask about specific and individual types of treatment approaches, as "all patient care is individual and multilayered, involving many types of different co-treatments and therapies.
"However, since we know chemotherapy suppresses the immune system, leaving patients vulnerable to infections, we did want to explore this one further," he said.
Four in 10 (41 percent) said they had seen a rise in patients developing drug-resistant infections in the last year, with 23 percent of their cancer patients developing an infection during treatment on average.
As many as 65,000 cancer patients are at risk of catching a superbug infection after having surgery in the U.K. in this decade, the data suggested. Among the doctors surveyed, 5 percent of their patients who had surgery developed an infection which didn't respond to antibiotics.
A total of 86 percent of the doctors said the bugs Staphylococcus, E. coli and pseudomona put cancer patients at the most risk of serious harm. The research also highlighted frustrations clinicians have with the way infections are diagnosed, with 60 percent saying laboratories take too long to identify them in their patients.
Berman said in a statement: "Oncologists are right to be concerned about growing levels of antibiotic resistance being experienced by their patients post-surgery or those undergoing chemotherapy. We cannot change the rules of biology to stop superbugs appearing but we can slow their development and improve infection control and prevention."
The research comes as experts try to stem the rise of bugs which can't be treated with antibiotics. According to the U.N., at least 700,000 people die each year from drug-resistant infections. Research cited in the report states that figure could spike to ten million by 2050.
Berman highlighted in the report: "No new class of antibiotics has been discovered since the 1980s and the lack of market incentives for research and development has led the pharmaindustry to largely abandon projects developing new treatments.
"Even with significant subsidies for research and recent efforts by the U.K. and U.S. to increase payments for new antibiotics, the market is still sluggish and recent antibiotic [research and development] biotech bankruptcies have rung alarm bells amongst the medical community."
Berman told Newsweek we all have our part to play in stopping antibiotic resistance getting worse, including by listening to healthcare professionals who tells us not to use antibiotics unless necessary.
Citing data released late last year by the U.S. Centers for Disease Control and Prevention that more than 2.8 million antibiotic-resistant infections occur in the US each year, and more than 35,000 people die as a result, Berman said "we can conclude that U.S.-based oncologists will share the same concerns as their U.K. counterparts."
For cancer patients worried by the findings, Berman stressed: "Today, patients on chemotherapy can be assured that the vast majority of infections can be successfully prevented or treated with antibiotics.
"This research is rather a wake-up call to say that we need new diagnostic tests so that we can better deploy antibiotics to ensure that they keep working. If resistance levels continue to rise, the problem will become more acute."
Berman added: "Ultimately, antibiotic resistance can affect anyone, of any age, anywhere in the world and these figures should act as a wake-up call to us all."
This article has been updated with comment from Daniel Berman.
